Dr Leong's research interests include clinical drug trials, inflammatory bowel disease epidemiology, biomarker discovery and advanced endoscopic imaging including confocal laser endomicroscopy and panoramic endoscopy. He is widely published in these fields including in the top ranked specialty journal Gastroenterology and Gut. Dr Leong has been awarded prestigious research grants, fellowships and prizes including from the National Health and Medical Research Council (NHMRC) of Australia and Gastroenterological Society of Australia.  

​"My research aims to find simple, translatable and cost-effective solutions to common gastrointestinal problems and to develop preventative measures or early detection through screening." 

Clinical drug trials

Dr Leong is principle investigator for several multi-centre clinical drug trials mostly in inflammatory bowel diseases at Concord and Macquarie University Hospitals. These trials are approved by the Human Research Ethics Committee and certified on Please discuss with me if you are interested in participating.

IBD epidemiology

Prof Leong is the current chair of the following research groups or resources: 
Sydney IBD Cohort

Persistence in Australian IBD Cohort (PANIC) national registry 

IBD in the Asia Pacific region

- consensus guidelines development


PhD/MD/Masters Students

Dr Christian Selinger (MD) 

Dr Dorothy Chow (MD) 

Dr Yunki Yau (PhD) 

Dr Crispin Corte (PhD) 

Dr Jeff Chang (PhD) 

Dr Viraj Kariyawasam (PhD) 

Dr Jo chen (Masters) 

Dr Nikola Mitrev (Masters) 

Dr Hadis Mirzaei  (Masters) 

Dr Craig Haifer (PhD) 

Dr Brandon Baraty (PhD)  

Dr Aviv Pudipeddi (PhD) 

Dr Cheng Lee (PhD) 

Dr Robyn Laube (PhD)

Dr Gokal Tamilarasan (PhD)

IBD biomarkers

Proteomics and Metabolomics in IBD

IBD endoscopy

Confocal laser endomicroscopy 

Leaky gut in inflammatory bowel diseases and controls. 

Full Spectrum Endoscopy

and dysplasia (FUSION Study)

Artificial Intelligence: Computer Aided Diagnosis in confocal laser endomicroscopy

Bowel Cancer

SUCCESS Study: Sydney of Colorectal Cancer Screening Study (enrolling) please see your GP

Colonoscopy quality, improving mean adenoma detection rates 

IBD patient outcomes
IBD patient outcomes

Entyvio Lengthen Dost Interval Study (ELDIS) 

Vedolizumab Immunomodulator Enforced Withdrawal Study (VIEWS) 

Quality of life, disability 

- validation of Chinese IBDQ 

- IBD Disability Index 

Pregnancy knowledge 

IBD gut microbiome
IBD gut microbiome

Consensus guidelines on faecal microbiota transplantation (FMT) 

FMT therapeutics and clinical trials 

Consensus guidelines on faecal microbiota transplantation (FMT) 

FMT therapeutics and clinical trials


Collaboration with the AIMS group and UNSW  

Endoscopy outcomes

Consensus guidelines on faecal microbiota transplantation (FMT) 

FMT therapeutics and clinical trials 

Macquarie University Hospital
Suite 404, 2 Technology Place, Macquarie Uni:
T: (612) 9812 3880
Specialist Medical Services, Sydney
Level 11, 501 George St, Sydney:
T: (612) 8378 1721  

© Rupert Leong

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