Research

Dr Leong's research interests include clinical drug trials, inflammatory bowel disease epidemiology, biomarker discovery and advanced endoscopic imaging including confocal laser endomicroscopy and panoramic endoscopy. He is widely published in these fields including in the top ranked specialty journal Gastroenterology and Gut. Dr Leong has been awarded prestigious research grants, fellowships and prizes including from the National Health and Medical Research Council (NHMRC) of Australia and Gastroenterological Society of Australia.  

​"My research aims to find simple, translatable and cost-effective solutions to common gastrointestinal problems and to develop preventative measures or early detection through screening." 

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Clinical drug trials

Dr Leong is principle investigator for several multi-centre clinical drug trials mostly in inflammatory bowel diseases at Concord and Macquarie University Hospitals. These trials are approved by the Human Research Ethics Committee and certified on clinicaltrials.gov. Please discuss with me if you are interested in participating.

PhD/MD/Masters Students

Dr Christian Selinger (MD) 

Dr Dorothy Chow (MD) 

Dr Yunki Yau (PhD) 

Dr Crispin Corte (PhD) 

Dr Jeff Chang (PhD) 

Dr Viraj Kariyawasam (PhD) 

Dr Jo chen (Masters) 

Dr Nikola Mitrev (Masters) 

Dr Hadis Mirzaei  (Masters) 

Dr Santosh Sanagapalli (PhD)

Dr Craig Haifer (PhD)   

Dr Aviv Pudipeddi (PhD) 

Dr Cheng Lee (PhD) 

Dr Sri Selvaratnam (MRes) 

Dr Robyn Laube (PhD)

Dr Gokal Tamilarasan (PhD)

IBD endoscopy

Confocal laser endomicroscopy  identifies leaky gut in IBD

Leaky gut in inflammatory bowel diseases and controls. 

Full Spectrum Endoscopy

and dysplasia (FUSION Study)

Artificial Intelligence: Computer Aided Diagnosis in confocal laser endomicroscopy

IBD epidemiology

IBD in the Asia Pacific region

- consensus guidelines development (APAGE) 

- epidemiology of IBD in the Chinese population

First Australian metropolitan prevalence study: Sydney IBD cohort  

IBD biomarkers

Proteomics and Metabolomics in IBD


Bowel Cancer

SUCCESS Study: Sydney of Colorectal Cancer Screening Study (enrolling) please see your GP

Colonoscopy quality, improving mean adenoma detection rates 

IBD patient outcomes
IBD patient outcomes

IBD disability index validation 

Quality of life,

- validation of Chinese IBDQ 

- IBD Disability Index 

IBD Pregnancy knowledge, consensus guidelines development

 

Chaired Australian Therapeutic Drug Monitoring (TDM) consensus (GESA)   

IBD gut microbiome
IBD gut microbiome

Consensus guidelines on faecal microbiota transplantation (FMT) 

FMT therapeutics and clinical trials 

Consensus guidelines on faecal microbiota transplantation (FMT) 

FMT therapeutics and clinical trials

 

Clinical lead, Australian IBD Microbiome study (AIMS)    

IBD biological agents

Sydney IBD Cohort

Persistence Australian National IBD Cohort (PANIC) registry

- comparative effectiveness research 

Entyvio Lengthen Dost Interval Study (ELDIS) 

Vedolizumab Immunomodulator Enforced Withdrawal Study (VIEWS)