Professor Rupert Leong 

Professor Rupert Leong is a consultant gastroenterologist and Professor of Medicine of University of Sydney (clinical), The University of New South Wales (conjoint) and Macquarie University in Sydney, Australia. His private rooms are based at Macquarie University Hospital Clinic and in the Sydney central business district. 

Professor Rupert Leong is a Senior Staff Specialist gastroenterologist, Director of Endoscopy and Head of the Inflammatory Bowel Disease Services at Concord Hospital, Clinical Professor of Medicine at University of Sydney, UNSW, and Macquarie University, Sydney Australia. He is the Clinical Discipline Head of Gastroenterology at Macquarie University Hospital and the previous Career Development Fellow (level 2 clinical) of the NHMRC.

Prof Leong has appeared on ABC Catalyst, the Today Show, Nine National News, Channel 10 News, and features regularly on news forums relating to research and new advances in gastroenterology medications or endoscopic procedures.   


Prof Leong has published over 210 high quality scientific journals publications including senior authorships in Nature Reviews, Gastroenterology, Gut, Gastrointestinal Endoscopy and Endoscopy. Amongst these are senior authorship of national and international consensus guidelines in both Australia and in Asia. He is section editor of the Journal of Gastroenterology and Hepatology and on the international editorial boards of the American Journal of Gastroenterology, Alimentary Pharmacology and Therapeutics and Gastrointestinal Endoscopy.


Prof Leong is an executive member of a number of government bodies including the Agency for Clinical Innovation of NSW Health nominated for expertise in IBD and the Cancer Council of Australia Working Party on the revision of the clinical practice guidelines for colonoscopy and colorectal cancer, leading the section on surveillance colonoscopy in inflammatory bowel disease. Professor Leong was awarded the American Gastroenterological Association Fellowship by invitation on the basis of research excellence in 2012. He is the founding director of IBD Sydney, IBD School and IBD Masterclass. 

As a clinician, Prof Leong is widely recognized for his clinical management and endoscopy skills especially on the role of advanced imaging techniques, colon cancer diagnostic strategies and treatment of Crohn's disease strictures. He consults at Macquarie University Hospital (Suite 404, 2 Technology Place, Macquarie Uni 98123880) and in Sydney Central Business District (Specialist Medical Services, Level 11, 501 George St, Sydney 83781721). His global reputation has led to speaking engagements and live endoscopy demonstrations around the world including in USA, Germany, China, Hong Kong, Singapore. He is a primary supervisor of PhD, MPhil and Masters by Research students and has supervised international gastroenterology fellows from Hong Kong, Singapore, Malaysia, Philippines, Sweden, UK, Wales, Ireland and Northern Ireland. He is principal investigator of a number of clinical drug trials. 


Professor Leong completed his FRACP advanced training in Clinical Immunology and Gastroenterology in 2000 in Western Australia and was awarded the Amy and Athelstan Overseas Research Fellowship of University of Western Australia to conduct 2 years’ research as Visiting Scholar at The Prince of Wales Hospital, Shatin, Hong Kong. He completed his MD thesis (2004) on the Epidemiology of Inflammatory Bowel Diseases in the Chinese Population – the first comprehensive series of epidemiological studies of IBD in an Asian population. The novel research subsequently awarded Leong the Gastroenterological Society of Australia Researcher on the Rise, the Young Achiever Award of the Australian Chinese Medical Association and the American Gastroenterological Association Fellowship by invitation on the basis of research excellence. Leong conducted the first genetic research of IBD genes on the Chinese population [Leong RW, et al. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther. 2003;17:1465-70]. Prof Leong was nominated for Emerging Leader by the Gastroenterological Society of Australia (http://www.gesa.org.au/index.cfm//about-gesa/emerging-leaders-lectureship-jghf-nominees/) and in 2015 the Trans-Tasman lecturer of the Royal Australasian College of Physicians (http://www.gesa.org.au/about-gesa/trans-tasman-lecturers/)  speaking at the national conference in New Zealand and in 2017 the prestigious Nimmo lecturer and the site visitor of the new Royal Adelaide Hospital. 

Named Lectureships

In 2017, Leong was the Nimmo Lecturer, the named lectureship of the new Royal Adelaide Hospital. In 2015, Leong was the Trans-Tasman lecturer of the Royal Australasian College of Physicians and the New Zealand Society of Gastroenterology. 


Professor Leong was awarded the prestigious NHMRC Career Development Fellow (Clinical Level 2) in 2011. Leong has received prizes and awards including the Gastroenterological Society of Australia (GESA) Career Development Award, AstraZeneca Emerging Leader, the GESA Abbott IBD Research Award, UNSW Paper of the Year award, and the RACP Career Development Award. He supervises advanced gastroenterology trainees, Masters/ PhD students and medical students students. His students have been awarded NHMRC scholarships, Douglas Piper Young Investigator Clinical Award finalists, Institute of Digestive Diseases runner up and finalists, Concord Early Career Research Awards, Human Proteome Organization Early Career Research Travel Award and various posters of distinction at ECCO, DDW, and AGW.


Professor Leong is consultant gastroenterologist at Macquarie University Hospital (98123880), Specialist Medical Services (83781721), Concord Hospital Inflammatory Bowel Disease Clinic (97676111), Sydney Australia. 


Professor Leong’s research funding is in excess of $2.2M. His research funding has been from the NHMRC, Gastroenterological Society of Australia, Royal Australasian College of Physicians and industry partners. He is also the principle investigator of a number of multicentre clinical drug trials offering novel advanced therapeutics in the management of inflammatory bowel diseases. Research from these studies have resulted in their listing on the Therapeutic Goods Administration and reimbursement by the Pharmaceutic Benefits Scheme of Australia. 


Professor Leong has a track record of successfully supervising MPhil, PhD and MD candidates within Australia and from around the world. He teaches and supervises medical undergraduate and postgraduate students at UNSW, USyd and Macquarie University and has won teaching awards for his contributions. In 2012 he developed the IBD Sydney network to provide networking and educational events for NSW gastroenterologists. In 2016 he commenced IBD School, the national teaching course for Australian gastroenterology advanced trainees and IBD Masterclass in 2018 teaching junior gastroenterologists. 


Peer Review

Professor Leong was selected as external examiner for final MBChB medical professional examinations at Chinese University of Hong Kong in 2018. He has been a panel reviewer for research grants of the NHMRC. PhD examiner for University of Queensland, University of Melbourne. Academic promotion for University of Malaya.  



Professor Leong has served as executive of the Australian IBD Association and the Research Committee of GESA. He was invited to join and rejoin the Agency for Clinical Innovation of NSW Health Department.

About Professor Rupert Leong

Endoscopy and other Services

  • endoscopy: gastroscopy, colonoscopy in Sydney CBD (83781721) and Macquarie University Hospital (98123880). 

  • ​polypectomy, endoscopic mucosal resection

  • endoscopic ultrasound (EUS)

  • ​EUS Fine Needle Aspiration (FNA) 

  • confocal laser endomicroscopy

  • ​endoscopic cancer screening, polyp surveillance

  • ​clinical drug trials

  • inflammatory bowel diseases (IBD) 

  • research: epidemiology, endoscopy, confocal endomicroscopy 

  • Endoscopy Fellowship and observership

Sydney Local Health District 



Professor Rupert Leong has a H index of 44 (Google Scholar) and he has over 7,400 citations to date. He has over 180 peer-reviewed publications and book chapters including publications in top tiered gastroenterology journals [Leong RW, et al. In vivo confocal endomicroscopy in the diagnosis and evaluation of celiac disease. Gastroenterology. 2008;135:1870-6; Leong RW et al. Full-Spectrum Endoscopy Improves Surveillance for Dysplasia in Patients With Inflammatory Bowel Diseases https://doi.org/10.1053/j.gastro.2017.01.008]. His research on protein biomarkers resulted in patents on protein biomarkers that diagnose and differentiates phenotypes of IBD (AU 2013902409). In addition Leong has been involved in studying impaired intestinal mucosal epithelial barrier using new endoscopic technologies. This revolutionary research using a specialized endoscopic technology called confocal endomicroscopy presenting this research as a dedicated oral presentation forum at the Digestive Diseases Week, USA in 2013. Professor Leong is committed to improving the outcomes of inflammatory bowel diseases through finding novel endpoints, use new biomarkers and finding cost-effective solutions. He combines his expertise in performing endoscopic procedures with his knowledge and experience in managing inflammatory bowel diseases.  

Figure 1. Leaky gut identified in inflammatory bowel diseases. Published in Nature Reviews Gastroenterology and Hepatology, 2010

Figure 2. Professor Rupert Leong is interviewed in Malaysia 

Macquarie University Hospital
Suite 404, 2 Technology Place, Macquarie Uni:
T: (612) 9812 3880
Specialist Medical Services, Sydney
Level 11, 501 George St, Sydney:
T: (612) 8378 1721  

© Rupert Leong

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